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In a large, rigorous review of over 50 studies involving more than one million patients, metformin use in patients with type 2 diabetes was associated with a 35% reduction in risk of death from cancer, and a 27% reduction in risk of any cancer (Franciosi 2013)

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Safety Prior to randomization, one patient (of 224 enrolled participants) died, with no relationship between the death and the study or the supplement identified by the CIMATEC committee, since the death occurred prior to collect blood samples or consume the investigational supplement

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